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外泌体在胰腺癌研究中的进展

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 1

DOI:: 10.3760/cma.j.issn.1674-1935.2017.01.018

Key Word:: No keyword available

Abstract：外泌体(exosomes)是细胞主动分泌的小囊泡,起源于内涵体,直径约为40 ～ 150 nm.结构上,外泌体由脂质双层包裹细胞液而成,常含有线粒体、核糖体等细胞器.其囊液富含蛋白质如热休克蛋白、细胞信号蛋白等,以及核酸如信使RNA、小RNA、DNA等[1-4].过去的十余年里,针对肿瘤,尤其胰腺癌外泌体的研究呈现爆炸式增长.这些研究结果显示,外泌体参与肿瘤的增生、血管生成、凋亡抑制,同时促进上皮间质转化、侵袭及转移、诱导免疫耐受及耐药性形成[1,5].本文综述了外泌体在胰腺癌发生、发展中的重要作用,以及在肿瘤诊断、治疗方面的潜在价值.

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