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急性胰腺炎胰腺微循环障碍的发生机制及治疗

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 5

DOI:: 10.3760/cma.j.issn.1674-1935.2015.05.019

Key Word:: No keyword available

Abstract：急性胰腺炎( AP)是一种常见的需入院治疗的急性胃肠道疾病. 全球发病率可达13~45/100 000人,且发病率明显呈升高趋势[ 1-2 ]. 国内一项对北京市8所综合性医院2006年至2010年5年内的2 461例胰腺炎病例进行回顾性研究,发现胰腺炎发病总人数逐年上升,其中,736例表现为重症急性胰腺炎(SAP),占29.9%[3]. 而SAP通常表现为持续性器官功能衰竭或死亡,常累及1个或多个器官,并伴有局部并发症,病死率可高达36%~50%,当合并感染性坏死时,病死率则更高[4]. 胰腺炎的发病机制尚未完全阐明,目前被充分认可的有4种机制,胰腺的自身消化、过度炎症反应、胰腺微循环障碍以及肠道细菌易位[5]. 随着器官微循环的研究逐渐增多,胰腺微循环障碍在AP中的作用也越来越多地引起重视,研究表明胰腺微循环障碍在AP进展中起着极其重要的作用[6] ,且不同病因对胰腺微循环障碍作用机制不同. 本文就AP胰腺组织微循环障碍发生的机制及治疗方法进行综述.

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