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纳米刀治疗胰腺癌现状

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-1935.2014.06.019

Key Word:: No keyword available

Abstract：不可逆电穿孔(irreversible electroporation,IRE)消融技术是一种不依赖热量形式的新兴肿瘤消融技术.它利用微创电极针传递毫秒级电脉冲[1],形成外来电场改变细胞膜磷脂双分子层的跨膜电位,使细胞膜进行重排,细胞表面出现很多纳米级孔隙,导致细胞膜渗透压升高,当脉冲能超过某个电场阈值时,造成不可逆的细胞损伤,引起细胞凋亡并最终导致细胞死亡[2-3].近年来,该技术已开始运用于治疗肝癌[4-5]、肺癌[6-7]和肾癌[8-9],并在胰腺癌治疗领域进行了初步尝试.胰腺癌是一种高度恶性的消化道肿瘤,病死率高.究其原因主要是由于80％胰腺癌患者在确诊时已出现局部进展或转移,从而失去手术机会[10],且放化疗疗效不佳[11-12].

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