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Correlation between heart rate variability and inflammatory response in severe acute pancreatitis patients

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Author:
No author available
Journal Title:
Chinese Journal of Pancreatology
Issue:
6
DOI:
10.3760/cma.j.issn.1674-1935.2014.06.011
Key Word:
胰腺炎,急性坏死性;心率变异性;炎症因子;APACHEⅡ;Pancreatitis,acute necrotizing;Heart rate variability;Inflammatory cytokines;APACHE Ⅱ score

Abstract: Objective To evaluate the relationship between heart rate variability (HRV) and serum inflammatory cytokines (TNF-α,IL-6),procalcitonin (PCT) and acute physiology and chronic health evaluation (APACHE) Ⅱ score in severe acute pancreatitis (SAP) patients.Methods Forty-one SAP patients admitted to Department of General Surgery,Department of General Surgery,General Hospital of Nanjing Military Area Command within 72 hours of symptoms onset were included in this study.Five-minite ECG signals were obtained within 24 h of admission for HRV analyses.At the same time,blood sample were obtained,then TNF-α,IL-6,PCT were determined.APACHE Ⅱ score were recorded within 24 h of admission.Results Among the 41 SAP patients,there were 22 male and 19 female with a median age of 47 years old.The etiologies were as follows,20 biliary cases,7 alcoholic cases,9 hyperlipidemia cases and 5 other cases.The serum levels of TNF-α,IL-6,PCT were 455 μg/L (301.5-790.0 μg/L),334 μg/L(206.5-735.0 μg/L),0.3 pg/L(0.1-1.2 pg/L).The median APACHE Ⅱ score was 14 (range 11-18).The TP,LF,HF of HRV was 205.6(84.9-921.0),52.9(6.75-125.8),11.0(4.1-40.9) (ms × ms) ; and the nLF,nHF was 36.6 (13.7-64.3),10.2 (4.2-25.0) nu,while the LF/HF was 3.4 (1.7-6.8).The level of nHF was positively correlated with TNF-α,IL-6,PCT(r =0.849,0761,0.480,p < 0.01).The level of LE/HF was negatively correlated with TNF-α,IL-6,PCT(r =-0.525,-0.708,-0.325,p < 0.01 or 0.05).nHF was positively correlated with APACHE Ⅱ score (r =0.346,P < 0.05).However,LF/HF was not correlated with APACHE Ⅱ score.nLF was not correlated with other parameters.Conclusions Heart rate variability is closely correlated with TNF-α,IL-6 and PCT.

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