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Hedeghog信号通路与胰腺癌治疗研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-1935.2014.01.021
- Key Word:
- No keyword available
Abstract： 胰腺导管腺癌(简称胰腺癌)是消化系统常见的恶性肿瘤,占胰腺恶性肿瘤的90％以上,近年来发病率呈逐年上升趋势,居欧美国家癌症致死病因的第4位.近年来研究发现,Hedgehog信号通路(HH信号通路)在胰腺癌中有不同程度的异常活化,可能是胰腺癌的核心致病机制之一[1-2].同时,该通路的异常活化对胰腺癌的恶性生物学特性的维持极为重要[3-6],为研究胰腺癌的发生机制和治疗方案提供了全新的方向.目前已经发现或合成的多种化合物,可以在不同的环节阻断HH信号通路.本文就HH信号通路的阻断剂及其在胰腺癌治疗中的应用做一综述.
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