You Position: Home > Paper
那可丁对人胰腺癌BxPC3细胞中HIF-1α及其靶基因VEGF表达的影响
( views:328, downloads:68 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1935.2010.02.022
- Key Word:
- No keyword available
Abstract： @@ 缺氧诱导因子-1α(HIF-1α)是一种在哺乳动物组织中广泛存在的转录因子,它可诱导VEGF转录活性的增强和表达增加,在肿瘤细胞的能量代谢、血管生成、促进肿瘤增殖和转移中起重要作用[1].因此,抑制HIF-1α可能作为恶性肿瘤治疗的一个靶点.那可丁(noscapine)是一种阿片类生物碱.最新研究发现,那可丁能阻断HIF-1α的表达.此外,它还有抗血管形成的作用[2].本实验观察不同浓度的那可丁在氯化钴(CoCl_2)诱导缺氧的状态下对人胰腺癌细胞株BxPC3细胞中HIF-1α、VEGF基因表达的影响,探讨那可丁作为新的化疗药物治疗胰腺癌的可行性.
- [1]Jin-Rong Du,Ying Jiang,Yan-Mei Zhang,etc.Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas[J].2003,(7).
- [2]Ferrara N.Molecular and biological properties of vascular endothelial growth factor.[J].1999,77(7).
- [3]Zhong H,Simons JW,Giannakakou P,etc.2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.[J].2003,3(4).
- [4]Bunn HF,Schau M,Gu J,etc.Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.[J].1998,95(14).
- [5]Shanks J,Ye K,Petros J,etc.Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells.[J].1998,95(4).
- [6]Schnee T,Lukyanov Y,Lan L,etc.Noscapine inhibits hypoxia-mediated HIF-1alpha expression andangiogenesis in vitro: a novel function for an old drug.[J].2006,28(5).
- [7]Gerber HP.,Condorelli F.,Park J.,etc.Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes - Flt-1, but Not Flk-1/Kdr, is up-Regulated by Hypoxia[J].1997,272(38).