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The preventive effect of somatostatin on acute pancreatitis after intestinal ischemia reperfusion in macaques

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PANCREATOLOGY
Issue:
4
DOI:
10.3760/cma.j.issn.1674-1935.2007.04.001
Key Word:
胰腺炎;生长抑素;肠缺血再灌注

Abstract: 目的 观察肠缺血再灌注(intestinal ischemia reperfusion,IIR)对胰腺组织病理改变的影响及生长抑素(somatostatin,SST)的治疗作用.方法 15只健康猕猴分为对照组、IIR组、SST组,每组5只.放免法检测外周血SST含量,酶比色法测定血清淀粉酶及脂肪酶,ELISA法检测血清及小肠黏膜组织IL-1β、IL-6、TNF-α水平,镜下观察胰腺组织病理变化.结果 IIR组外周血SST为(62.17±13.56)pg/ml,较对照组的(160.61±33.84)pg/ml显著减少(P<0.05),血淀粉酶、脂肪酶、IL-1β、IL-6、TNF-α也均显著升高(P<0.05),胰腺组织出现病理性改变.SST组血SST水平为(156.32±30.25)pg/ml,较IIR组显著升高(P<0.05),血淀粉酶、脂肪酶IL-1β、IL-6、TNF-α均明显下降(P<0.05),胰腺组织病理改变减轻.结论 SST可预防IIR所导致的胰腺病理损伤.

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