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Effects of matrix metalloproteinase inhibitor BB-94 on acute pancreatitis associated lung injury in rats

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PANCREATOLOGY
Issue:
1
DOI:
10.3760/cma.j.issn.1674-1935.2005.01.010
Key Word:
基质金属蛋白酶类;胰腺炎,急性坏死性;肺损伤;Batimistat

Abstract: 目的探讨基质金属蛋白酶抑制剂对急性胰腺炎(AP)及其相关性肺损伤(APALI)的影响及其作用.方法腹腔注射L-精氨酸制备大鼠急性坏死型胰腺炎(ANP)模型.44只大鼠随机分为BB-94(40 mg/kg/24 h,诱导AP前腹腔注射BB-94 3次)治疗组和生理盐水对照组(20 ml/kg/24 h,诱导AP前腹腔注射生理盐水3次),每组各10只大鼠观察生存率,其余测定血清淀粉酶,胰腺和肺组织病理评分,明胶酶谱法检测MMP9和MMP2活性,检测肺脏髓过氧化酶(MPO)活性和肺血管Evans blue渗透性.结果 BB-94组生存率较对照组提高(100% vs 75%),血清淀粉酶明显降低(P < 0.01),肺的MMP9和MMP2活性明显降低(P < 0.01)、粒细胞浸润和蛋白渗漏明显降低(P < 0.05).结论 BB-94可减轻AP时胰腺和肺脏的病理变化,降低AP所引起的肺组织MMP9和MMP2活性和蛋白渗漏.

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