You Position: Home > Paper
The expression of gut peptides receptor on pancreatic endocrine tumors
( views:295, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-1935.2002.01.002
- Key Word:
- 胰腺内分泌肿瘤;胃肠多肽;受体;储磷放射自显影
Abstract： 目的研究胰腺内分泌肿瘤的胃肠多肽受体表达状况.方法采用储磷放射自显影技术显示和定量分析胰泌素、蛙皮素、肠血管活性多肽、胆囊收缩素、生长抑素受体在胰腺内分泌肿瘤的表达特征.结果胃泌素瘤表达蛙皮素、生长抑素受体,胰泌素和肠血管活性多肽受体,其中生长抑素受体亲和力及结合能力显著高于其它受体.肠血管活性多肽瘤表达生长抑素、肠血管活性多肽和B型胆囊收缩素受体,以B型胆囊收缩素受体亲和力及结合能力最高.胃泌素瘤或VIP瘤所表达的胰泌素、蛙皮素、肠血管活性多肽、胆囊收缩素和生长抑素受体均呈高亲和力、单结合位点特征.生长抑素瘤和胰高糖素瘤未能测得上述5种胃肠多肽受体.结论除生长抑素受体外,胃泌素瘤和肠血管活性多肽瘤还表达胰泌素、蛙皮素、肠血管活性多肽受体.
- [1]Virgolini, Irene,Raderer, Markus,Kurtaran, Amir,etc.Vasoactive Intestinal Peptide-Receptor Imaging for the Localization of Intestinal Adenocarcinomas and Endocrine Tumors.[J].1994,331(17).
- [2]J.B.M.J. Jansen,C.B.H.W. Lamers.Low binding of Bolton-Hunter-labelled cholecystokinin-33 to carboxyl-terminal CCK-antibodies[J].1982,51(2).
- [3]Tang C,Biemond I,Offerhaus GJA,etc.Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas[J].1997.
- [4]Cornells B.H.W. Lamers,Chengwei Tang,Leak Biemond.Localization and Quantification of Cholecystokinin Receptors in Rat Brain with Storage Phosphor Autoradiography[J].1995,18(5).
- [5]Ensinck J W,Laschansky E C,Vogel R E,etc.Circulating prosomatostatin-derived peptides. Differential responses to food ingestion.[J].1989.
- [6]R F, Johnston,S C, Pickett,D L, Barker.Autoradiography using storage phosphor technology.[J].1990,11(5).