You Position: Home > Paper
Value of the Combined Measurement of DKK-1 plus Alpha Fetoprotein in the Diagnosis of Hepatocellular Carcinoma:A Meta-Analysis
( views:16, downloads:10 )
- Author:
- No author available
- Journal Title:
- Journal of Military Surgeon in in Southwest China
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1672-7193.2021.04-06.002
- Key Word:
- DKK-1;甲胎蛋白;肝癌;Meta分析
Abstract： 目的 探讨血清标志物DKK-1联合甲胎蛋白(AFP)检测对比单项检测AFP对肝细胞癌(HCC)的诊断价值.方法 检索已发表的有关DKK-1联合AFP及单项AFP检测诊断HCC的文献,并提取数据.采用Me-ta-DiSc1.4软件对诊断准确度指标进行Meta分析.结果 最终7篇文献入选.异质性检验提示AFP、DKK-1单项检测、DKK-1联合AFP检测均不存在阈值效应,但存在由其他因素引起的异质性,故选择随机效应模型.分析显示:DKK-1联合AFP检测的总灵敏度、总特异度、阳性似然比(PLR)、阴性似然比(NLR)及95％CI分别为0.88(0.86-0.90)、0.84(0.82-0.86)、0.15(0.10-0.24)、45.17(21.40-95.32).SROC曲线下面积和Q指数分别为0.938、0.8749.结论 DKK-1联合AFP检测能显著提高HCC诊断的灵敏度,并且特异性仍保持在较高水平(0.84),有助于HCC的早期诊断与筛查.
- [1]苏锐,苏萌,路艳.血清 DKK1水平对肝细胞癌的诊断价值[J].2016,(16).
- [2]刘敏姬,陈维顺,肖鹏程,等.AFP与DKK1联合检测对原发性肝癌的诊断价值[J].2017,(10).
- [3]Seung Up, Kim,Jeon Han, Park,Hyon-Suk, Kim,etc.Serum Dickkopf-1 as a Biomarker for the Diagnosis of Hepatocellular Carcinoma.[J].2015,56(5).
- [4]Penny Whiting,Anne WS Rutjes,Johannes B Reitsma,etc.The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews[J].2003,3(1).
- [5]谭顺顺,国娇,何雨,等.血清Dickkopf1蛋白水平对原发性肝癌的诊断价值[J].2017,(13).
- [6]Harun, Erdal,?zlem, Gül Utku,Eylem, Karatay,etc.Combination of DKK1 and AFP improves diagnostic accuracy of hepatocellular carcinoma compared with either marker alone.[J].2016,(4).
- [7][Noauthornameavailable].EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma[J].2012,56(4).
- [8]Llovet JM,Bruix J.Novel advancements in the management of hepatocellular carcinoma in 2008.[J].2008,48(Suppl.1).
- [9]Bray Freddie,Ferlay Jacques,Soerjomataram Isabelle,etc.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].2018,68(6).
- [10]Thomas G, Bird,Polyxeni, Dimitropoulou,Rebecca M, Turner,etc.Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection.[J].2016.
- [11]Tadatoshi Takayama,Masatoshi Makuuchi,Setsuo Hirohashi,etc.Early hepatocellular carcinoma as an entity with a high rate of surgical cure[J].1998,28(5).