You Position: Home > Paper

Involvement of TRPA1 in formation of crush injury induced neuropathic pain and its mechanism

( views:3, downloads:0 )
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Key Word:
TRPA1;损伤;神经病理性疼痛;激活;TRPA1;Damage;Neuropathic Pain;Activation

Abstract´╝Ü The purpose of this study was to investigate whether activation of TRPA1 is involved in the formation of crush injury induced neuropathic pain and its mechanism. At 2 h and 4 h after administration of TRPA1 inhibitor, mice models presented significantly longer paw withdrawal thermal latency and lower cold pain ratings compared with those without intervention ( P<0.05) . Compared with those without intervention, the levels of TRPA1 protein in brain tissue of mice model were significantly lower at 2 h and 4 h of administration, with statistically significant difference ( P<0.05) . In summary, activation of TRPA1 plays an important role in regulation and transmission of neuropathic pain induced by crush injury.

  • This article has no references!
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615