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Involvement of TRPA1 in formation of crush injury induced neuropathic pain and its mechanism

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Author:
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Issue:
5
DOI:
10.3760/cma.j.cn115668-20220224-00037
Key Word:
TRPA1;损伤;神经病理性疼痛;激活;TRPA1;Damage;Neuropathic Pain;Activation

Abstract´╝Ü The purpose of this study was to investigate whether activation of TRPA1 is involved in the formation of crush injury induced neuropathic pain and its mechanism. At 2 h and 4 h after administration of TRPA1 inhibitor, mice models presented significantly longer paw withdrawal thermal latency and lower cold pain ratings compared with those without intervention ( P<0.05) . Compared with those without intervention, the levels of TRPA1 protein in brain tissue of mice model were significantly lower at 2 h and 4 h of administration, with statistically significant difference ( P<0.05) . In summary, activation of TRPA1 plays an important role in regulation and transmission of neuropathic pain induced by crush injury.

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