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Therapeutic efficacy and safety of hydroxychloroquine in treatment of osteoarthritis: A Meta-analysis

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Journal Title:
Chinese Journal of Biomedical Engineering
Key Word:
羟氯喹;骨关节炎;随机对照试验;Meta分析;Hydroxychloroquine;Osteoarthritis;Randomized controlled trial;Meta-analysis

Abstract´╝Ü Objective:To elucidate the efficacy of hydroxychloroquine (HCQ) in osteoarthritis (OA) via a Meta-analysis of randomized controlled trials (RCTs) .Methods:We used "hydroxychloroquine" and "osteoarthritis" as keywords for literature search in related databases. Only RCTs were included. The therapeutic efficacy and safety of HCQ were compared among the OA patients. A Meta-analysis with random-effect model was performed to assess the pain and function scales in the patients. Revman 5.3 software was used for Mmeta-analysis of the literature included.Results:Five RCT studies were finally included, comprising a total of 528 OA patients. The length of follow-up was 3 to 24 months. As shown by the Meta-analysis, the Western Ontario and McMaster Universities Arthritis Index (WOMAC) in 149 patients on HCQ [ SMD=0.10, 95% CI (-0.69, 0.89) , I2=0.85] and visual analogue score (VAS) of pain in 106 patients on HCQ [ SMD=0.02, 95%CI (-2.69, 2.73) , I2=0.00 ] were not statistically different compared with the control group. There was no statistical difference in adverse reactions between the two groups. Conclusion:The therapeutic efficacy and pain-relieving effect of hydroxychloroquine as a treatment of osteoarthritis differ across studies, rendering further research needed.

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