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Diagnostic performance of a combination test panel including CA19-9, CA72-4, CEA, PG I and PG Ⅱ in gastric cancer

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Author:
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Issue:
4
DOI:
10.3760/cma.j.cn115668-20211118-00141
Key Word:
胃肿瘤;生物标志物;诊断技术和方法;微点阵分析;蛋白质组学;Gastric neoplasms;Biomarkers;Diagnostic techniques and methods;Microarray analysis;Proteomics

Abstract: Objective:To investigate the clinical value of combination test panel including carbohydrate antigen 19-9 (CA19-9) , CA72-4, carcinoembryonic antigen (CEA) , pepsinogens (PG) Ⅰ and Ⅱ in diagnosing gastric cancer (GC) .Methods:The serum samples of 50 GC patients and 50 others with non-neoplastic gastric disease (NGD) admitted to the Department of Gastroenterology, Beijing Jishuitan Hospital were included consecutively in the study. The serum levels of CA19-9, CA72-4, CEA, PG Ⅰ and PG Ⅱ were tested quantitatively by the GC biomarker quantibody microarray kits. The efficiency of these biomarkers detected alone or in combinations in diagnosing GC was calculated.Results:The levels of these five indicators in the GC group were significantly higher than those in the NGD group ( P<0.05) . The area under the ROC curve (AUC) for these indicators detected alone in diagnosing GC ranged between 0.586 (95% CI: 0.471-0.701) and 0.811 (95% CI: 0.719-0.902) , lowest with CA72-4 and highest with PG Ⅱ. The AUC of combination test panel including CA19-9, CA72-4 and CEA was slightly lower than the panel including PGs Ⅰ and Ⅱ[0.797 (95% CI: 0.710-0.885) vs 0.814 (95% CI: 0.724-0.905) ]. The AUC of the combination test panel including all the indicators above was the highest, which further rose to 0.875 (95% CI: 0.800-0.943) . Conclusion:Combined detection of conventional serological tumor markers and pepsinogens by quantibody microarray kits has potential value in assisting the diagnosis of GC, which justifies widespread use in practices.

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