Abstract： Objective:Objectives To study the clinical characteristics of patients with cardiac amyloidosis (CA) , find clues for early diagnosis, and improve the diagnosis process.Methods:Fourteen patients with CA confirmed by pathology were reviewed in our hospital from January 2016 to December 2019. Their clinical manifestations, laboratory examinations, electrocardiogram (ECG) , echocardiogram (UCG) , cardiac magnetic resonance imaging (CMR) , 99mTc-PYP myocardial imaging were collected. Results:Eleven cases presented congestive heart failure. Main features of ECG were low voltage in limb leads, poor R wave increments in left chest lead and pathological Q wave, which occurred in 12 cases. UCG showed different degree of left ventricular wall thickening. Eight patients underwent CMR, 7 of them showed delayed gadolinium enhanced scan. Among the 8 patients who underwent 99mTc PYP radionuclide myocardial rest imaging, 3 cases had 2-3 grades myocardial uptake, and 1 had grade 2 myocardial uptake, all of them were ATTR. UCG showed different degrees of left ventricular wall thickening. During the follow-up period of 1 to 3.5 years, 3 patients died, 2 patients were discharged automatically, and 9 patients improved. Conclusions:The clinical manifestations of CA lack specificity. The combined finding of UCG and ECG were early diagnostic clues. Combination CMR, 99mTc-PYP myocardial imaging and extracardiac tissue biopsy can prove the diagnosis of CA.