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Clinical value of early neutrophil ? to ? lymphocyte ratio changes in predicting prognosis of intracerebral hemorrhage

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Author:: No author available

Journal Title:: Chinese Journal of Biomedical Engineering

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-1927.2019.02.022

Key Word:: 脑出血;中性粒细胞;淋巴细胞;预后;炎症;Intracerebral hemorrhage;Neutrophils;Lymphocytes;Prognosis;Inflammation

Abstract： Objective To investigate the relationship between the changes of early neutrophil?to?lymphocyte ratio (NLR) and the prognosis of acute intracerebral hemorrhage (AICH). Methods The clinical data of 160 AICH patients admitted to our hospital between January 2014 and October 2018 were retrospectively analyzed. According to the modified Rankin Scale(mRs)scores,all patients were divided into the good prognosis group and poor prognosis group. NLR was determined at different time points, including the time points at admission(T1),24?48h after admission(T2),and 6?7d after admission(T3). The differences in clinical features and NLR between the two groups were compared,and the correlation between NLR and clinical features was analyzed. Logistic regression analysis was used to determine the risk factors for the prognosis of intracerebral hemorrhage. Results NLRs at T2 and T3 in the poor prognosis group were significantly higher than those in the good prognosis group(both P<0.05). Correlation analysis showed that NLRs at T2 and T3 were positively correlated with the volume of blood loss,ICH scores and mRS scores,and negatively correlated with GCS scores(all P<0.001). Logistic regression analysis showed that NLRs at T2 and T3 were risk factors for poor prognosis of AICH(P<0.05). Conclusion Early changes in NLR after admission are clinically significant in predicting poor prognosis of AICH.

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