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Study of motor evoked potential by transcranial electric stimulation for model rabbits with lumbar spinal canal stenosis

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Author:
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Issue:
1
DOI:
10.3760/cma.j.issn.1674-1927.2018.01.007
Key Word:
脊髓损伤;腰椎椎管狭窄;动物模型;运动诱发电位;评估;Spinal cord injury;Lumbar spinal stenosis;Animal model;Motor evoked potentials;Evaluation

Abstract: Objective To establish the animal model of lumbar spinal stenosis to determine the relationship between the motor evoked potential of transcranial electrical stimulation(TES-MEP)and lower extremity function and the pathology of spinal cord injury,and to investigate the clinical value of TES-MEP. Methods Thirty-two New Zealand white rabbits were randomly divided into the control group and three study groups (mild group,moderate group,and severe group). The control group was received surgical treatment alone. The study groups were implanted with silica gel columns of 1,2 and 3 mm diameters under the L5 lamina.The evoked potentials were recorded at 5 min,1,3 and 7 d after the anesthesia and silica gel column implantation-induced stenosis with stable waveforms. At the same time,the Tarlov motor function score was used to evaluate the motor function. The middle segment of spinal cord was taken for pathological section at 7 d,and the pathological changes of spinal cord injury were examined under microscope. Results The TES-MEP latency at 5 min after the operation in the mild group was longer than that in the control group (P<0.05). The TES-MEP latency at different time points after the operation in the moderate and severe groups was significantly longer compared with that in the control group(P<0.05). The TES-MEP amplitude ratio and lower extremity function score significantly decreased in the study groups compared with those in the control group(all P<0.05). There were statistically significant differences in the TES-MEP latency,MEP amplitude ratio and lower extremity function score among the study groups(all P<0.05),and the neuronal damage of spinal cord was aggravated. The Spearman's correlation analysis showed that the lower extremity function was positively correlated with the TES-MEP latency(r=-0.813,P<0.01),whereas was negatively correlated with the amplitude ratio (r=0.961, P<0.01) after the catheterization in the study groups. Conclusion TES-MEP is significantly correlated with lower extremity function and pathological injury of spinal cord. The sensitivity of TES-MEP amplitude change is better than that of latent period .

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