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白念珠菌白-灰转换相关因素的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Biomedical Engineering

Issue:: 5

DOI:: 10.3760/cma.j.issn.1674-1927.2015.05.020

Key Word:: No keyword available

Abstract：近年来,随着器官移植和各种侵入性诊疗技术的普遍开展、免疫抑制剂、糖皮质激素和广谱抗生素等在临床上广泛应用,免疫缺陷患者,尤其是艾滋病患者不断增多,念珠菌感染逐年增加,其发病率近10年来升高了约5倍,其中以白念珠菌占主导地位[1].白念珠菌是一种常见的条件致病性真菌,常寄居于正常人的皮肤、粘膜等部位,与健康人群处于共生状态.当机体免疫力下降或使用免疫抑制剂时,白念珠菌常可引起皮肤、粘膜、内脏器官感染,甚至导致侵袭性念珠菌血症.白念珠菌的毒力因子包括粘附素、侵袭性酶、表型转换及生物膜的形成等[2].表型转换可以帮助白念珠菌适应宿主的组织环境,从而逃避人类免疫系统的杀伤作用[3].白念珠菌可进化出多种形态,不同形态的转换能力与白念珠菌致病力密切相关.越来越多的研究表明,白念珠菌致病性与其表型转换密切相关[2].其中研究最多的是酵母形态-菌丝形态和白菌-灰菌形态之间的转换.本文将对影响白-灰转换的环境因素和转录因子进行综述.

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