Abstract: Objective To evaluate the value of infrared thermal imaging (IRTI) in detection of peripheral vasculopathy in asymptomatic smokers. Methods From April to May in 2013,80 asymptomatic smokers who had smoked for 15?40 years were evaluated for blood supply to the lower extremities by using IRTI in our hospital. Based on the smoking amount,the subjects were divided into heavy smokers group(≥25 pack?years,n=45) and light smokers group (<25 pack?years,n=35). Measurements of IRTI were performed for each subject in quadruplicate in a uniform body posture. The average temperature of the following 10 points at the both lower limbs were recorded and compared between groups:D1?D5 (digit pedis),AA(anterior ankle?feet midpoint),DP(dorsalis pedis),AP(posterior ankle?feet midpoint),MM (malleolus medialis),and ML (malleolus lateralis). Results There were significant differences in the mean age(42.89 ± 8.82 vs 53.26 ± 6.37 y/o)and smoking history(18.24 ± 4.18 vs 29.34 ± 4.87 pack years) between the light and heavy smokers(P<0.05),but not in gender,body weight,body mass index(BMI), and family history (P>0.05). After adjusting for age, statistical difference was found in the mean temperatures at all points except for D3(P=0.06)between the two groups(P<0.05). Conclusion IRTI might be clinically valuable in assessing distal vasculopathy in asymptomatic smokers,although validation with stratified analysis of larger sample is needed.