Abstract： Objective To compare the efficacy of continuous blood purification (CBP) and conventional therapy in the treatment of heat stroke (HS).Methods Clinical data of 22 patients with HS in our hospital from January 2000 to July 2013 were retrospectively analyzed.Patients were divided into CBP group (n=14) and conventional therapy group (n=8) according to the treatment of CBP or convention.The hypothermia time and mortality were compared,and the levels of serum creatinine (Scr),blood urea nitrogen (BUN),ALT,AST,creatine kinase (CK) were compared between two groups on admission and before hospital discharge.Results The hypothermia time in CBP group decreased significantly than that in conventional therapy group [(11.92±7.44) h vs (30.50± 11.70) h,P＜0.05].There was no significant difference in the levels of Scr,BUN,ALT,AST,CK in two groups on admission (all P＞0.05).Compared with the conventional therapy group,the decrease values of Scr,BUN,ALT,AST,CK were significant higher in CBP group before hospital discharge (all P＜0.05) . Mortality was lower in CBP group than that in conventional therapy group [14.3％ (2/14) vs 62.5％ (5/8),P＜0.05].Conclusion CBP shows significant advantages compared with the conventional therapy,and may be an important method for early treatment of HS.