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Serum golgi protein 73 for early diagnosis and surveillance of hepatocellular carcinoma

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Author:
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Issue:
1
DOI:
10.3760/cma.j.issn.1674-1927.2014.01.004
Key Word:
癌,肝细胞;早期诊断;甲胎蛋白类;高尔基体蛋白73;Carcinoma,hepatocellular;Early diagnosis;alpha-fetoprotein;Golgi protein-73

Abstract: Objective To evaluate the diagnostic value of serum gholgi protein 73 (GP73) and alpha-fetoprotein (AFP) for early-stage hepatocellular carcinoma (HCC).Methods The enzyme linked immunosorbent assay (ELISA) and eletrochemiluminescence immunoassay were employed to determine the level of serum GP73 and AFP in 77 patients with HCC,21 patients with liver cirrhosis,20 patients with hepatitis and 59 healthy subjects for further comparison and analysis.Results The levels of serum GP73 and AFP in HCC were significantly higher than those in cirrhosis,hepatitis and healthy controls (all P< 0.05).Patients with early-stage HCC had a markedly higher level of GP73 than those with liver cirrhosis (P< 0.05).However,there was no significant difference of AFP between these two groups (P>0.05).The diagnostic sensitivity of GP73 for HCC was significantly higher than that for AFP (85.7% vs 62.3%,P< 0.05).The combination detection was associated with an increased sensitivity (90.9%).Conclusions GP73 is an ideal serum marker for the diagnosis of liver diseases and monitoring of disease progression.The combination detection with AFP effectively improves the diagnosis accuracy of HCC.

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