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急性肾损伤生物标志物的研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Biomedical Engineering
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1674-1927.2011.05.022
- Key Word:
- No keyword available
Abstract： 急性肾衰竭(ARF)是危重症患者常见并发症和重要死亡原因,近年来,针对ARF的病理生理和发病机制方面取得了长足的进展,但ARF的病死率并未得到改善[1].目前,国际肾脏病和急救医学界趋向将ARF改为急性肾损伤(AKI),其涵盖了从肾功能微小改变到最终肾衰竭的整个过程,是包括ARF、急性肾小管坏死(ATN)、移植肾延迟恢复功能(DGF)等一大组疾病在内的临床术语.它能更贴切地反映疾病的基本性质,且对早期诊断和治疗具有更积极的意义[2].传统的血肌酐和尿量虽然是AKI分期的依据,但对于其早期诊断缺乏特异性和敏感性,不能精确地反映出肾脏损伤的部位和肾功能的变化.因此,探索新的生物学标志物,对早期发现和诊断AKI有重要意义.现就近年来研究的AKI生物标志物综述如下.
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