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Apelin在心力衰竭中的作用的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Biomedical Engineering

Issue:: 5

DOI:: 10.3760/cma.j.issn.1674-1927.2011.05.021

Key Word:: No keyword available

Abstract： 1998年Tatemoto等[1]首次提取并纯化的Apelin是孤儿G蛋白偶联受体APJ(angiotensinⅡprotein J)的内源性配体,在组织中分布广泛.Apelin的表达异常与心力衰竭的发生发展密切相关,在人类和动物的研究中均显示补充Apelin能够改善心功能.近来Apelin在心力衰竭中的作用被广泛关注,本文就其最新进展做一综述.

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