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Meta-analysis of the cytochrome P4501A1 gene MSP Ⅰ site and GSTM polymorphisms as correlated with Individual susceptibility to lung cancer in Chinese population

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Author:
No author available
Journal Title:
Chinese Journal of Biomedical Engineering
Issue:
4
DOI:
10.3760/cma.j.issn.1674-1927.2011.04.016
Key Word:
细胞色素P4501A1基因;GSTM基因;基因多态性;肺癌;易感性;Cytochrome P4501A1 gene;GSTM gene;Gene polymorphism;Lung cancer;Susceptibility

Abstract: Objective To investigate the effects of CYP1A1 MSPI and GSTM polymorphisms on lung cancer susceptibility in Chinese population by meta-analysis. Methods Criteria for inclusion/exclusion of literatures were developed and used in this study. Search of relevant literatures was conducted by two independent scientists. According to the inclusion criteria, the odd ratios (OR) and 95% confidence intervals (CI) for lung cancer among individuals with different combinations of genotypes were listed. Based on the results of test for heterogeneity in odd ratios, several models (fixed effect model, random effects model) were used to obtain the pooled data of OR, 95% CI and P value. Results A total of 12 articles involving 13 populations were obtained. Using the genotype combination CYP1A1 (w/w) plus GSTM (+) as the reference category, the pooled OR and 95%CI of CYP1A1 (w/m) plus GSTM (+), CYP1A1 (m/m) plus GSTM (+),CYP1A1 (w / w) plus GSTM (-), CYP1A1 (w / m) plus GSTM (-) and CYP1A1 (m / m) plus GSTM (-)was (1.22, 0.95-1.57), (1.24, 0.88-1.76), (1.51, 1.07-2.12), (1.82, 1.30-2.54), and (2.06, 1.56-2.72) , respectively. Conclusions The heterozygous or homozygous CYP1A1 MSPI variant plus GSTM deletion in a given individual can significantly increase the risk for lung cancer. Genotyping as a measure for primary prevention should be emphasized in lung cancer screening.

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