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A simplified method for PET absolute quantification analysis

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
Issue:
6
DOI:
10.3760/cma.j.issn.1674-1927.2009.06.010
Key Word:
正电子发射断层显像术;计算机;模拟;血流动力学;参数预测;示踪剂动力学模型;Positron- emission tomography;Computer,simulation;Hemodynamics;Parameter estimation;Tracer kinetic modeling

Abstract: Objective To establish a simplified PET absolute quantification analysis method which avoids arterial blood sampling and reducse the total time of dynamic PET imaging.Methods Plasma time activity curve (PTAC) of left ventricle was obtained by outlining the region of interest (ROI) in PET images.Through a combination of PTAC ROI and standardized input function model, whether definite non-invasive input function may be used as an alternative to serial arterial sampling was further validated.Then, an algorithm using curve fitting [input function model for PTAC, output function model for tissue time activity curve (TTAC)] and numerical solution of differential equation was proposed to obtain a compartment model of glucose metabolism.Computerized simulation and experimental validation of this putative algorithm was completed with regard to its capacity to reduce the total time of dynamic PET imaging. Result (1) Comparison of ki values obtained with the measured and the fitted input curves showed that both procedures gave consistent results using nonlinear least squares (NLS) methods (r=0.9824, P<0.01).(2) Under low or medium noise level condition, computerized simulation results revealed that as short as 25 minutes of dynamic PET sampling could be feasible for FDG-PET full kinetic analysis.The result of animal tumor model showed ki_(60)=0.9127 × ki_(25)-0.0013 when dynamic PET sampling was reduced to 25 min (r=0.9182, P<0.01).Conclusion Non- invasive input function can be obtained with assistance of proper selected plasma, meanwhile, serial arterial sampling may be avoided and time duration of dynamic PET imaging is reduced using the method proposed in this study.

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