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Expression of HER-2 and C-myc mRNA in benign prostatic hyperplasia and prostate cancer

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
Issue:
4
DOI:
10.3760/cma.j.issn.1674-1927.2009.04.010
Key Word:
前列腺肿瘤;癌基因;逆转录聚合酶链反应;基因;HER-2;前列腺增生;Prostatic neoplasms;Oncogenes;Reverse transcriptase polymerase chain reaction;Genes;HER-2;Prostatic hyperplasia

Abstract´╝Ü Objective To study the HER- 2/C- myc mRNA expression in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) tissue, and to explore the value of HER-2/C-myc mRNA expression in PCa diagnosis. Methods A sensitive, real-time fluorescence quantitative (FQ) PCR assay was used to detect the differential expression of HER-2 and C- myc mRNA in prostate samples from 63 patients with PCa, 37 with BPH and 3 healthy controls. Results The expression levels of HER-2 (4.25± 0.03) and C-myc (7.24±0.06) in PCa tissue were significantly higher than those in BPH (both P<0.05). Conclusion The detection of HER-2 and C-myc mRNA expression by FQ-PCR may provide reliable and helpful information for the diagnosis of PCa.

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