You Position: Home > Paper

Value of serous and urinary cystatin C for the diagnosis of early kidney injury in diabetic patients

( views:330, downloads:4 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
Issue:
2
DOI:
10.3760/cma.j.issn.1674-1927.2009.02.005
Key Word:
半胱氨酸蛋白酶抑制剂;糖尿病;肾功能试验;ROC曲线;肾小管;Cysteine proteinase inhibitors;Diabetes;Kidney function tests;ROC curve;Kidney tubules

Abstract: Objective To detect the changes of serous and urinary cystatin C concentration compared with clinic general renal function indexs, and to evaluate the value of cystatin C for the diagnosis of early kidney injuryin diabetic patients. Methods Eighty-two patients preliminayily diagnosed as diabetes were divided into three groups according to the degree of 24 hours urinary microalbumin quantitation. Twenty-eight healthy volunteers were selected as control. Serous cystatin C, serous creatinine, urinary cystatin C, urinary N-acetyl-β-d-glucosaminidase (NAG), urinary α1-microglobulin(α1-MG), 99mTc-DTPA glomerular filtration rate (99mTc-GFR) and creatinine clearance rate resulted from Cockcroft-Gault equation (Ccr-GFR) were measured and statistical analysis was performed. Results The concentration and abnormal rate of urinary cystatin C increased before those of serous cystatin C were higher. Correlation between serous cystatin C and 99mTc-GFB was superior to that between Ccr-GFR and 99mTc-GFR (r=-0.88 vs r=0.84, P< 0.01). Correlation between urinary cystatin C and NAG was similar to that between urinary cystatin C and α1-MG (r=0.89 vs r=0.90, P<0.01). Area under curve of receiver operating characteristic (AUCROC) of serous cystatin C and Ccr-GFR was significantly different (0.897±0.094 vs 0.757±0.228, P<0.01). AUCROC of urinary cystatin C was superior to that of NAG (P<0.05), and no difference to that of α1-MG was found(P> 0.05). Likelihood ratio (LR) of urinary cystatin C was superior to that of serous cystatin C. Conclusion Serous and urinary cystatin C concentration can diagnose early diabetic kidney injury, which can earlier reflect impairment of kidney tubule than that of glomerulum.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn