Expression of tumor stem cell marker CD166 in colorectal carcinoma and its clinical significance
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-1927.2008.04.010
- Key Word:
- 肿瘤干细胞;结直肠肿瘤;CD166;肿瘤标志物;Dukes分期;腺癌;Tumor stem cell;Colorectal neoplasm;CD166;Tumor marker;Dukes stage;Adenocarcinona
Abstract： Objective To evaluate the expression of CD166 in colorectal carcinoma (CRC) tissues in order to explore its significance in CRC pathogenesis. Methods The expression of CD166 mRNA was detected by RT-PCR in CRC tissues and normal colorectal tissues outside the cancers in 23 patients with confirmed CRC. Its association with clinicopathological parameters was analyzed. Results The positive rate (95.7%) and expression level (0.309±0.145) of CD166 mRNA in CRC tissues were statistically higher than those of 39.1% and 0.109±0.255 in the normal colorectal tissues (P<0.01). No significant association of CD166 mRNA expression with age, gender, Dukes stages, tumor locations, tumor sizes or histological types of CRC was found. Conclusion CD166 mRNA expression is up-regulated in CRC tissues, which is not associated with clinicopathological parameters.
- [1]T, Lapidot,C, Sirard,J, Vormoor,etc.A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.[J].1994,367(6464).
- [2]Swart GW,Lunter PC,Kilsdonk JW,etc.Activated leukocyte cell adhesion molecule (ALCAM/CD166): Signaling at the divide of melanoma cell clustering and cell migration?[J].2005,24(2).
- [3]Wicha MS,Al Hajj M,Benito Hernandez A,etc.Prospective identification of tumorigenic breast cancer cells.[J].2003,100(7).
- [4]Tahan SR,Klein-Szanto AJ,Wu H,etc.Increased expression of stem cell markers in malignant melanoma.[J].2007,20(1).
- [5]T, Reya,S J, Morrison,M F, Clarke,etc.Stem cells, cancer, and cancer stem cells.[J].2001,414(6859).
- [6]Kaiser S,Stephan C,Hinzmann B,etc.Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival.[J].2005,205(3).
- [7]Verma A,Shukla NK,Deo SV,etc.MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma.[J].2005,68(4).
- [8]Agnieszka, Jezierska,Wojciech P, Olszewski,Jerzy, Pietruszkiewicz,etc.Activated Leukocyte Cell Adhesion Molecule (ALCAM) is associated with suppression of breast cancer cells invasion.[J].2006,12(7).