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Emotion and memory effects of midazolam on primipara undergoing caesarean section

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
Issue:
5
DOI:
10.3760/cma.j.issn.1674-1927.2007.05.012
Key Word:
咪达唑仑;剖宫产;情绪;记忆;Midazolam;Caesarean section;Emotion;Memory

Abstract: Objective To investigate the emotion and memory effects of midazolam as a premedication on primipara undergoing caesarean section. Methods Seventy-two primiparous women scheduled for elective caesarean section were randomly divided into four groups. In group Ⅰ,Ⅱand Ⅲ,intramuscular midazolam 0.05 mg/kg,0.06 mg/kg and 0.07 mg/kg were given respectively. The primiparae in group Ⅳ were given intramuscular normal saline 1.5 ml. Anxiety vision analogy test(AVAT) , state anxiety index testing(SAIT) and Ramsay score were evaluated before and 30 min after injection of above drugs. The primiparae were informed when several stages of anesthesia and surgery began. Four hours after the caesarean section they would recall those stages. Accurate remembrance was recorded. Results Thirty minutes after injection,AVAT declined by 36.4% ,43.2% ,43.1% in group Ⅰ,Ⅱand Ⅲ respectively,while SAI decreased by 20.9% ,24.8% ,26.9% respectively. Ramsay 2~4 levels were attained in all the primiparae. There was significant difference between treatment groups and control group in scores of memory (P<0.01). Most primiparae in treatment groups forgot the process of venipuneture, but all maternals could recall the process of anesthesia and identify the gender of neonates. Conclusions Good sedation and anxiolysis can be obtained when midazolam 0.05~0.07mg/kg as premedicaton is used for caesarean section,which affect effects on the explicit memory in part, and produces anterograde amnesia effect on the small amount and little-attention information, while keeps panmnesia of the large amount and close-attention information.

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