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Expression of DNA Repair Enzyme MGMT in Human Brain Gliomas and Its Biological Implication
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-634X.2005.03.010
- Key Word:
- 神经胶质瘤;MGMT;P53
Abstract： 目的探讨MGMT及P53蛋白在人脑胶质瘤中的表达及其与肿瘤发生和恶性度的关系.方法对39例人脑胶质瘤标本用免疫组化法检测MGMT和P53蛋白的表达,观察两者的相互关系及其和肿瘤恶性度间的关系.结果不同恶性程度胶质瘤间MGMT的阳性表达率无明显区别(p＝0.496745),但表达强度却明显不同(p＝0.018781),两者呈明显的负相关(r＝-0.629,p<0.05).P53蛋白的阳性表达率(p=0.027648)和表达强度(p=3.5×10-118)在不同恶性程度肿瘤间都有明显差异,与肿瘤的恶性程度呈正相关(r＝0.575,p<0.05).MGMT的阳性表达强度和P53蛋白的阳性表达强度呈明显的负相(r=-0.750,p<0.05).结论 MGMT表达减弱和P53表达增强与脑胶质瘤的发生及其恶性程度有一定关系.
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