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亚甲基四氢叶酸还原酶基因多态性与习惯性流产关系研究
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1927.2003.03.036
- Key Word:
- 流产;亚甲基四氢叶酸还原酶;基因突变
Abstract： 目的探讨广东地区汉族妇女亚甲基四氢叶酸还原酶基因多态性与习惯性流产关系.方法采用多聚酶链式反应限制性片段长度多态分析(PCR-RFLP)的方法,对50例习惯性流产和56例正常对照的广东地区汉族妇女进行MTHFR677C→T突变检测.结果习惯性流产组与正常对照组之间基因型的分布有显著差异:χ2=11.07,p<0.05;但两组间等位基因突变频率无显著差异:χ2=2.06,p>0.05.流产组677C→T突变纯合子(24.0%)较对照组((7.1%)明显升高.等位基因突变频率流产组(26.0%)较对照组(17.9%)升高.结论 MTHFR 677C→T纯合子突变与习惯性流产有明确的相关关系.
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