You Position: Home > Paper
Changes of Plasma Endothelin and Nictric Oxide in Hypertension Treated with Enalapril and Arotinolol
( views:235, downloads:8 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-1927.2000.04.012
- Key Word:
- 原发性高血压;内皮素;一氧化氮;依那普利;阿罗洛尔
Abstract： 目的探讨内皮素(ET)、一氧化氮(NO)在高血压发病和治疗学中的意义.方法 60例原发性高血压(EH)患者随机分为两组,分别口服依那普利(5～10mg/d)及阿罗洛尔(20～30mg/d),疗程为6周.放免法测定治疗前后血浆ET、NO水平.结果 EH患者血ET水平较对照组明显升高(p<0.05),NO水平明显降低(p<0.001) ,组内Ⅰ、Ⅱ期患者间亦有明显差异(p<0.01).治疗后,依那普利组血ET明显降低,NO明显升高(p<0.05),Ⅱ期变化幅度较Ⅰ期大( p<0.05).阿罗洛尔组ET、NO水平无变化(p> 0.05).结论 ET、NO在高血压发病中起重要作用,依那普利可改善血管内皮,阿罗洛尔则无此作用.
- [1]J R, Cockcroft,P J, Chowienczyk,S E, Brett,etc.Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism.[J].1995,274(3).