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Effect of Nicotinamide on Patients with Type-1 Diabetes Mellitus
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1927.2000.02.009
- Key Word:
- 烟酰胺(NAA) 1型糖尿病(1-DM)
Abstract： 目的探讨烟酰胺(Nicotinamide,NAA)对1型糖尿病(1-DM)的防治作用.方法 NAA 1.2g/m2.d治疗1型糖尿病48例,连续口服4个月.结果 16例血基础C-肽(CP)和胰高糖素刺激后6分钟C-肽(6'-CP)显著升高;其中8例出现蜜月期,5例胰岛细胞抗体(ICA)和胰岛素自身抗体(IAA)均阳性,3例为ICA阳性;蜜月期发生于治疗后第3～12周;随访18个月,其中5例需恢复INS治疗.其余的32例治疗并随访12个月以上,C-肽有上升趋向.结论烟酰胺对1型糖尿病早期的胰岛β细胞有一定的保护作用.
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