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Contributions of impaired adult hippocampal neurogenesis to occurrence and development of diabetic encephalopathy

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2022.0040

Key Word:: 糖尿病脑病;成年海马神经发生;神经炎症;神经干细胞

Abstract：糖尿病脑病(diabetic encephalopathy,DE)是糖尿病的常见并发症之一.持续的高血糖可引起机体慢性炎症、血脑屏障通透性增加、神经发生障碍和脑萎缩等形态和功能的改变,从而导致认知功能下降.海马齿状回(dentate gyrus,DG)是机体调节学习记忆功能的重要区域,也是哺乳动物成年神经发生的重要脑区之一.最新研究表明,成年海马神经发生(adult hippocampal neurogenesis,AHN)在整个生命进程中持续存在,随着年龄的增长而降低,但在DE中受损明显.DE中AHN障碍引起认知功能损伤的机制日益受到关注.本文就近年来AHN障碍在DE发生、发展中的作用及机制的研究进展进行综述,以期为DE的防治提供新的思路.

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