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Regulation of Toll-like receptors and their downstream factors by butyrate

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2022.0073

Key Word:: 炎症;Toll样受体;丁酸盐;微小核糖核酸;高迁移率族蛋白B1;G蛋白耦联受体

Abstract：丁酸盐是一种常见的肠道细菌代谢产物,不仅为细胞提供能量,还能改变胞内某些蛋白的磷酸化、乙酰化和甲基化水平,进而影响相关基因表达和细胞信号传递.丁酸盐还可以通过G蛋白耦联受体促进肠道黏液分泌和上皮屏障形成,降低致病菌及其代谢产物对人体的影响.Toll样受体(Toll-like receptors,TLRs)是一类模式识别受体,其活化引起胞内链式反应,进而导致核因子κB(nuclear factor κB,NF-κB)活化,促进其从细胞质转入细胞核,最终引起多种促炎因子和趋化因子的分泌和表达.此外,TLRs的表达还与一些炎症性疾病和肿瘤发生有关.本文旨在阐述丁酸盐对TLRs及其下游信号通路的影响,总结了在炎症和肿瘤条件下丁酸盐的产生与TLRs表达的关系及其两者相互作用对机体产生的影响,进而讨论了丁酸盐作为细菌代谢物在治疗相关疾病中的潜在价值.

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