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Research progress on mechanism of exercise improving non-alcoholic fatty liver disease through regulating endoplasmic reticulum stress

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2022.0055

Key Word:: 非酒精性脂肪性肝病;运动;内质网应激;分子机制

Abstract：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是代谢综合征的主要疾病之一.随着NAFLD在全球范围内的日益流行,NAFLD的防治面临巨大的挑战.近些年,国内外学者针对NAFLD开展了大量研究,但其发病机制仍不清楚.内质网应激(endoplasmic reticulum stress,ERS)是由未折叠或错误折叠蛋白的积累所引起,作为对ERS的反应,细胞通过启动未折叠蛋白反应(unfolded protein response,UPR)的保护机制来帮助恢复正常的内质网功能.肝细胞脂质异常积聚、炎症反应加剧、肝细胞凋亡增加和胰岛素抵抗(insulin resistance,IR)是NAFLD的主要发病因素和特征,与肝脏ERS密切相关.大量研究表明,运动作为一种低成本治疗手段,可有效预防和改善NAFLD,其机制与运动调节ERS水平相关.本文从ERS的角度,综述运动改善NAFLD的作用机制研究进展.运动改善NAFLD的机制与运动通过调节ERS来调控肝细胞脂质代谢、减轻炎症反应、减少肝细胞凋亡和改善IR有关.

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