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CircRNA-0028171 regulates arsenic trioxide-induced apoptosis in vascular endo-thelial cells

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Author:
No author available
Journal Title:
Acta Physiologica Sinica
Issue:
5
DOI:
10.13294/j.aps.2022.0047
Key Word:
环状RNA;血管内皮细胞;三氧化二砷;凋亡

Abstract: 本文旨在研究circRNA-0028171对三氧化二砷(As2O3)诱导的血管内皮细胞凋亡的调控作用.用0-15 μmol/LAs2O3作用人脐静脉血管内皮细胞(human umbilical vein endothelial cells,HUVECs)24 h,用MTT法检测HUVECs损伤情况,用实时定量PCR检测circRNA-0028171及凋亡相关蛋白Bcl-2、BaxmRNA表达水平,用Western blot检测Bcl-2、Bax蛋白表达水平.通过转染circRNA-0028171过表达质粒和siRNA观察circRNA-0028171是否参与As2O3对HUVECs的调控.结果显示,与对照组相比,As2O3组细胞活性显著下降,Bcl-2/BaxmRNA比值和蛋白比值显著降低,circRNA-0028171显著低表达.过表达circRNA-0028171抑制As2O3诱导的HUVECs凋亡,而敲减circRNA-0028171促进As2O3诱导的HUVECs凋亡.上述结果提示,circRNA-0028171参与调控As2O3诱导的血管内皮细胞凋亡过程.

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