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Effects of acute fear stress on spatial memory and neuronal plasticity in the medial prefrontal cortex in mice

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2022.0075

Key Word:: 恐惧;GABA能神经元;锥体神经元;全细胞记录;小鼠

Abstract：本研究旨在通过检测急性恐惧应激对小鼠空间检索能力以及内侧前额叶皮层(medial prefrontal cortex,mPFC)神经元可塑性的影响,探讨mPFC神经元可塑性变化与应激后记忆调节之间的关系.选取6周龄雄性C57BL/6品系小鼠,随机分成对照组和应激组,对应激组小鼠足底施加电流刺激以建立急性恐惧应激模型,通过Morris水迷宫检测小鼠空间记忆的改变,通过全细胞记录检测边缘前皮质(prelimbic cortex,PrL)和边缘下皮质(infralimbic cortex,IL)锥体神经元和GABA能神经元动作电位发放的变化.结果显示:与对照组相比,急性恐惧应激可显著提高小鼠僵直百分比、僵直次数,降低平均速度,缩短获得性定位训练中的定位潜伏期,增加空间探查训练中在第一象限内探查停留时间,缩短在第三象限内探查停留时间,同时可显著提高小鼠PrL区GABA能神经元和IL区锥体神经元动作电位间距、能障和绝对不应期,降低PrL区锥体神经元和IL区GABA能神经元动作电位间距、能障和绝对不应期.以上结果表明:急性恐惧应激增强了小鼠空间记忆的学习和巩固能力,上调PrL兴奋性和功能,下调IL兴奋性和功能,提示应激后mPFC亚区的可塑性变化可能对空间记忆学习过程有一定的调控作用.

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