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Research progress of eicosanoid metabolomics in cardiovascular diseases

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2021.0061

Key Word:: 类二十烷酸;花生四烯酸;代谢组学;动脉粥样硬化;心肌梗死

Abstract：类二十烷酸是一类由多不饱和脂肪酸代谢而成的脂质活性分子.近年来,类二十烷酸在心血管系统疾病中的作用和调控机制受到广泛关注.在哺乳动物体内,类二十烷酸主要由花生四烯酸和其他多不饱和脂肪酸经四种途径代谢生成,包括环氧化酶途径、脂氧化酶途径、细胞色素P450氧化酶途径以及自发氧化途径.由于类二十烷酸代谢调控呈现出高度复杂的网络特性,因此,代谢组学成为系统研究类二十烷酸代谢网络调控的有效策略.本文将对类二十烷酸的生物合成及其功能、类二十烷酸代谢组学的研究策略及其在心血管疾病中的应用和研究进展进行综述,以期为心血管系统生理过程调控机制提供理论基础以及为临床精准治疗提供新的思路和策略.

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