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Role of adrenergic receptors in tumorigenesis and development of glioma

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 2

DOI:: 10.13294/j.aps.2020.0011

Key Word:: 脑胶质瘤;肾上腺素能受体;应激;肿瘤生长

Abstract：脑胶质瘤是侵袭能力极强的恶性肿瘤,目前治疗策略主要是手术治疗辅助放射治疗、化学治疗和免疫治疗等多种治疗,但疗效有限.肾上腺素能受体(adrenergic receptor,AR)是体内一种重要的应激激素受体,AR通过激活下游不同信号转导通路广泛参与调节多种肿瘤的发生与发展进程.最近研究显示,AR在脑胶质瘤细胞以及组织中表达失调,在脑胶质瘤的发生、侵袭和转移等一系列生物学行为中发挥着重要作用.本文对近年来AR在脑胶质瘤发生和发展中的研究进展进行综述,为以AR为靶点的脑胶质瘤的预防和治疗提供理论依据.

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