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Research advances in relationship between biological clock and cardiovascular diseases

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2019.0066

Key Word:: 生物钟;昼夜节律;心血管疾病;心肌梗死;动脉粥样硬化;高血压

Abstract：昼夜节律广泛存在于生命体中,主要由生物钟调控,使生命活动呈现以24 h为周期的变化.越来越多的研究表明,生物钟与心血管的生理功能密切相关,比如基础血压和心率的日周期变化主要受控于生物钟而非行为.此外,心肌细胞的代谢、血管内皮的功能,以及血管的收缩和舒张均受到生物钟的调节.不仅如此,许多心血管事件的发生,如心肌梗死的发生也具有明显的昼夜节律特征.基于动物模型的研究显示,昼夜节律紊乱是心血管事件发生的重要风险因素之一.本文综述了有关生物钟与心血管疾病联系的最新研究进展,希望有助于根据生物钟理论优化心血管疾病治疗策略.

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