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Macrophages polarization and their role in chronic obstructive pulmonary disease

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2019.0055

Key Word:: 巨噬细胞;巨噬细胞极化;慢性阻塞性肺疾病

Abstract：巨噬细胞具有高度可塑性,在炎症因子的诱导和多种信息分子的调控下可极化为经典活化巨噬细胞(M1)和替代活化巨噬细胞(M2).慢性肺部炎症反应和肺实质损伤是慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的主要病理表现.M1促进肺部炎症反应;M2抑制炎症反应,参与肺组织损伤与修复,并吞噬和清除病原微生物和凋亡细胞.靶向干预巨噬细胞极化方向有可能成为COPD治疗的新策略.

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