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Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2019.0041

Key Word:: 脂联素;血管内皮保护;机制

Abstract：糖尿病合并心血管疾病的发病率和死亡率逐年上升,已成为威胁人类健康的首要公共卫生问题.而高糖/高脂所致内皮细胞急性功能障碍与慢性结构损伤是糖尿病心血管病的重要始动因素.脂联素是由脂肪细胞分泌的具有细胞保护作用的内源性蛋白,大量研究表明,脂联素对高糖所致的血管内皮损伤具有保护效应.本文就脂联素减轻糖尿病血管内皮急性功能障碍和慢性结构损伤的保护机制作一综述.

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