Paper - WANFANG MED ONLINE

You Position: Home > Paper

The cardiovascular protection of irisin and its research progress in sports field

( views:61, downloads:0 )

Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2019.0032

Key Word:: 鸢尾素;心血管疾病;运动;血管内皮障碍

Abstract：鸢尾素(irisin)是一种运动诱导骨骼肌分泌的肌肉因子,是由Ⅲ型纤连蛋白组件包含蛋白5(fibronectin type Ⅲ-domain containing protein 5,FNDC5)剪切、修饰后分泌到血液中的多肽性片段.鸢尾素可以使白色脂肪棕色化,增加机体能耗,减轻体重.鸢尾素在糖尿病、冠心病等多种疾病的代谢过程中发挥着重要的作用,不同类型的运动对血液循环中鸢尾素水平的影响不同,而适度运动可以减轻心血管疾病症状.本文对鸢尾素的心血管保护作用及其在运动领域的研究进展作一综述,以期为心血管疾病的预防和治疗提供新的靶点.

Reference

[1]王焱,刘英,谢玮莉,等.冠心病患者血清鸢尾素与冠状动脉病变严重程度相关性分析[J].2016,(4).
[2]卢俊颜,向光大,梅稳,等.鸢尾素改善载脂蛋白E基因敲除糖尿病小鼠动脉粥样硬化[J].2015,(5).
[3]王小龙,刘同祥,赵新祥,等.慢性心力衰竭患者体内Irisin水平的变化及临床价值的研究[J].2015,(16).
[4]Aydin,S.,Kuloglu,T.,Yilmaz,M.,etc.Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running[J].2013,50.
[5]Besse-Patin,A.,Montastier,E.,Vinel,C.,etc.Effect of endurance training on skeletal muscle myokine expression in obese men: Identification of apelin as a novel myokine[J].2014,38(5).
[6]Aydin,S.,Kuloglu,T.,Eren,M.N.,etc.Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle[J].2014,52.
[7]Herrington, William,Lacey, Ben,Sherliker, Paul,etc.Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease[J].2016,118(4).
[8]Fang, Han,Shuxian, Zhang,Ningning, Hou,etc.Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway.[J].2015,309(9).
[9]Li Ye,Mengnan Xu,Xianming Tan,etc.TRPV4 is involved in irisin-induced endothelium-dependent vasodilation[J].2018,495(1).
[10]Xiaoyong, Qiao,Ying, Nie,Yaxian, Ma,etc.Corrigendum: Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways.[J].2016.
[11]Junhao, Huang,Shen, Wang,Fengpeng, Xu,etc.Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study.[J].2017,5(Spec ).
[12]Pontus Bostroem,Jun Wu,Mark P. Jedrychowski,etc.A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J].2012,481(Jan.26 TN.7382).
[13]Zhang,Y.,Li,R.,Meng,Y.,etc.Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling[J].2014,63(2).
[14]Kraemer,R.R.,Shockett,P.,Webb,N.D.,etc.A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women[J].2014,46(2).
[15]Pulliero, A.,Godschalk, R.,Andreassi, M. G.,etc.Environmental carcinogens and mutational pathways in atherosclerosis[J].2015,218(3).
[16]Arturo, Roca-Rivada,Cecilia, Castelao,Lucía L, Senin,etc.FNDC5/irisin is not only a myokine but also an adipokine.[J].2013,8(4).
[17]Febbraio MA,Pedersen BK.Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?[J].2005,33(3).
[18]Hou, Ningning,Han, Fang,Sun, Xiaodong.The relationship between circulating irisin levels and endothelial function in lean and obese subjects[J].2015,83(3).
[19]Salogiannnis,J.,Laznik-Bogoslavski,D.,Greenberg,M.E.,etc.Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway[J].2013,18(5).
[20]Tolga Han, Efe,Burak, A?ar,Ahmet G?ktu?, Ertem,etc.Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina.[J].2017,47(1).
[21]Timea Kurdiova,Miroslav Balaz,Alexer Mayer,etc.Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes[J].2014,56.
[22]Eren, M. N.,Kuloglu, T.,Aydin, S.,etc.Alteration of serum and cardiac tissue adropin, copeptin, irisin and TRPM2 expressions in DOX treated male rats[J].2015,90(1/8).
[23].Resistance training increases fibroblast growth factor-21 and irisin levels in the skeletal muscle of Zucker diabetic fatty rats.[J].2017,21(3).
[24]Hofmann, Tobias,Elbelt, Ulf,Stengel, Andreas.Irisin as a muscle-derived hormone stimulating thermogenesis - A critical update[J].2014,54.
[25]Alan T Hirsch.Vascular disease, hypertension, and prevention: “from endothelium to clinical events”[J].2003,42(2).
[26]Junyan Lu,Guangda Xiang,Min Liu,etc.Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice[J].2015,243(2).
[27]Lee,P.,Linderman,J.D.,Smith,S.,etc.Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans[J].2014,19(2).
[28]Lee, Hye Jeong,Lee, Jung Ok,Kim, Nami,etc.Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK[J].2015,29(6).
[29]Brook RD.Obesity, weight loss, and vascular function.[J].2006,29(1).
[30]Yan Z,Benton CR,Lira VA,etc.PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.[J].2010,299(2 Pt.1).
[31]Pekkala,S.,Wiklund,P.K.,Hulmi,J.J.,etc.Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?[J].2013,591(21).
[32]Peirang Cao,Alexandra Zavin,Daniel E Forman,etc.Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure.[J].2012,5(6).
[33]Daniel P. Kelly.Irisin, Light My Fire[J].2012,336(Apr.6 TN.6077).
[34]Frode Norheim,Torgrim Mika Langleite,Marit Hjorth,etc.The effects of acute and chronic exercise on PGC-1a, irisinand browning of subcutaneous adipose tissue in humans[J].2014,281(3).
[35]Panati, K.,Suneetha, Y.,Narala, V. R..Irisin/FNDC5-An updated review[J].2016,20(4).
[36]Roger A Vaughan,Randi Garcia-Smith,Marco Bisoffi,etc.Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells[J].2012,11.
[37]Hisamatsu, Takashi,Miura, Katsuyuki,Arima, Hisatomi,etc.Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study[J].2018,267.
[38]María, Pardo,Ana B, Crujeiras,María, Amil,etc.Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.[J].2014,2014.
[39]Kim, Hee-Jae,Lee, Hyo-Joo,So, Byunghun,etc.Effect of Aerobic Training and Resistance Training on Circulating Irisin Level and Their Association With Change of Body Composition in Overweight/Obese Adults: a Pilot Study[J].2016,65(2).
[40]An S De Vriese,Tony J Verbeuren,Johan Van de Voorde,etc.Endothelial dysfunction in diabetes[J].2000,130(5).
[41].Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses[J].2015,87.
[42]Tuncay Kuloglu,Suna Aydin,Mehmet Nesimi Eren,etc.Irisin: A potentially candidate marker for myocardial infarction[J].2014,55.
[43]Milan K. Piya,Alison L. Harte,Kavitha Sivakumar,etc.The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes[J].2014,306(3 Pt.1).
[44]Erden, Yavuz,Tekin, Suat,Sandal, Suleyman,etc.Effects of central irisin administration on the uncoupling proteins in rat brain[J].2016,618.
[45]Aydin,S.,Kuloglu,T..Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus[J].2013,47.