Paper - WANFANG MED ONLINE

You Position: Home > Paper

Advances on the anti-infiammatory and protective effect of AMPK activators

( views:29, downloads:0 )

Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 2

DOI:: 10.13294/j.aps.2018.0094

Key Word:: 腺苷酸活化蛋白激酶;AICAR;A-769662;二甲双胍;脂联素;AMP-activated protein kinase;AICAR;A-769662;metformin;adiponectin

Abstract： AMP-activated protein kinase(AMPK) is a key enzyme in the regulation of cellular energy homeostasis.Recent studies demonstrated that AMPK also plays an important role in the modulation of infiammation,an energy-intensive molecular response.The commonly used AMPK activators include 5-aminoimidazole-4-carboxamide ribonucleotide(AICAR) and A-769662.In addition,the biological activities of metformin and adiponectin are closely related to activation of AMPK.Numerous studies have shown that these AMPK activators play an effectively protective role in animal models of acute lung injury,asthma,colitis,hepatitis,atherosclerosis and other infiammatory diseases.Therefore,AMPK activators may have promising potential for the prevention and treatment of infiammation related diseases.

Reference

[1]Xiangcheng Zhang,Futai Shang,Liangliang Hui,etc.The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism[J].2017,25(4).
[2]Xu, Ningbo,Zhang, Yixin,Zhang, John H.,etc.Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats[J].2018,133.
[3]Guha M,Mackman N.The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells.[J].2002,277(35).
[4]Surya, Ramachandran,Vinitha, Anandan,V Raman, Kutty,etc.Metformin attenuates effects of cyclophilin A on macrophages, reduces lipid uptake and secretion of cytokines by repressing decreased AMPK activity.[J].2018,(Spec ).
[5]Nikhil, Mulchandani,Weng-Lang, Yang,Mohammad Moshahid, Khan,etc.Stimulation of Brain AMP-Activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis.[J].2015,21.
[6]Hardie, D. Grahame.AMPK: positive and negative regulation, and its role in whole-body energy homeostasis[J].2015,33.
[7]Ma, Ang,Wang, Jing,Yang, Liu,etc.AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE(-/-) mice[J].2017,58(8).
[8]Guigas B,Sakamoto K,Taleux N,etc.Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators[J].2009,61(1).
[9]Declèves A.-E.,Sharma K.,Satriano J..Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers[J].2014,128(3-4).
[10]Steinberg, Gregory R..Cellular Energy Sensing and Metabolism-Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture[J].2018,67(2).
[11]Wei-Lun, Tsai,Tsung-Hsien, Chang,Wei-Chi, Sun,etc.Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase.[J].2017,8(54).
[12]Joungmok, Kim,Goowon, Yang,Yeji, Kim,etc.AMPK activators: mechanisms of action and physiological activities.[J].2016.
[13]Velagapudi, Ravikanth,El-Bakoush, Abdelmeneim,Lepiarz, Izabela,etc.AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia[J].2017,435(1).
[14]Sun Ryoung, Choi,Ji Hee, Lim,Min Young, Kim,etc.Adiponectin Receptor Agonist AdipoRon Decreased Ceramide, and Lipotoxicity, and Ameliorated Diabetic Nephropathy.[J].2018,(Spec ).
[15]Yang, Changming,Gong, Xianqiong,Ai, Qing,etc.5-Aminoimidazole-4-carboxamide-1 beta-D-ribofuranoside alleviated carbon tetrachloride-induced acute hepatitis in mice[J].2015,25(2).
[16]Pascual Sanz,Teresa Rubio,Maria Adelaida Garcia-Gimeno.AMPKbeta subunits: more than just a scaffold in the formation of AMPK complex[J].2013,280(16).
[17]Piao, Chunxian,Park, Jeong Hyun,Lee, Minhyung.Anti-Inflammatory Therapeutic Effect of Adiponectin Gene Delivery Using a Polymeric Carrier in an Acute Lung Injury Model[J].2017,34(7).
[18]Hardie, D. Grahame,Schaffer, Bethany E.,Brunet, Anne.AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs[J].2016,26(3).
[19]Steinberg GR,Kemp BE.AMPK in Health and Disease.[J].2009,89(3).
[20]Deng, Jun,Zeng, Lishan,Lai, Xueying,etc.Metformin protects against intestinal barrier dysfunction via AMPKα1‐dependent inhibition of JNK signalling activation [J].2018,22(1).
[21]Raoni Freitas Carvalho,Ajax Mercês Atta,Isabela Silva de Oliveira,etc.Adiponectin levels and insulin resistance among patients with chronic hepatitis C[J].2018,178.
[22]C, Peralta,R, Bartrons,A, Serafin,etc.Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia-reperfusion injury in the rat.[J].2001,34.
[23]Kwon,H.-S.,Bang,B.-R.,Kim,T.-B.,etc.Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase[J].2012,84(12).
[24]Fumiaki, Kumase,Kimio, Takeuchi,Yuki, Morizane,etc.AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages.[J].2016.
[25]Sun, Xiaofei,Yang, Qiyuan,Rogers, Carl J.,etc.AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression[J].2017,24(5).
[26]Michael, Troncone,Stephanie M, Cargnelli,Linda A, Villani,etc.Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy; translational biology and rationale for current clinical trials.[J].2017,(Spec ).
[27]Sang-Min, Jeon.Regulation and function of AMPK in physiology and diseases.[J].2016.
[28]Kim, Yaeni,Lim, Ji Hee,Kim, Min Young,etc.The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes[J].2018,29(4).
[29]Niria, Trevi?o-Salda?a,Gerardo, García-Rivas.Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals.[J].2017,2017(Spec ).
[30]van Denderen BJW,Honeyman JE,Scott JW,etc.Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase beta 1-Containing Complexes[J].2008,15(11).
[31]S C, Bridgeman,G C, Ellison,P E, Melton,etc.Epigenetic effects of metformin: from molecular mechanisms to clinical implications.[J].2018,(Spec ).
[32]Kotagiri, Sasikumar,Mallappa, Sreevidya,Kotamraju, Srigiridhar,etc.Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction[J].2018,1864(4 Pt.A).
[33]Tarek A M, Almabrouk,Anna D, White,Azizah B, Ugusman,etc.High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.[J].2018,9(Spec ).
[34]Wang, Guizuo,Song, Yang,Feng, Wei,etc.Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1 and SOD1[J].2016,12(3 Pt.A).
[35]Rebecca C.Rabinovitch,BozenaSamborska,BrandonFaubert,etc.AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species[J].2017,21(1).
[36]Liu, Lu,Pan, Yilin,Song, Yang,etc.Activation of AMPK alpha 2 inhibits airway smooth muscle cells proliferation[J].2016,791.
[37]Cornelia Platzer,Eckhard Fritsch,Thomas Elsner,etc.Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells[J].1999,29(10).
[38]Mocanu MM,Paiva MA,Davidson SM,etc.Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.[J].2010,24(1).
[39]Obeid, Stephanie,Wankell, Miriam,Charrez, Berenice,etc.Adiponectin confers protection from acute colitis and restricts a B cell immune response[J].2017,292(16).
[40]Sid,B.,Glorieux,C.,Valenzuela,M.,etc.AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells[J].2014,91(2).
[41]Carles Canto,Zachary Gerhart-Hines,Jerome N. Feige,etc.Ampk Regulates Energy Expenditure By Modulating Nad~+ Metabolism And Sirt1 Activity[J].2009,458(Apr.23 TN.7241).
[42]Soori, Hosna,Chamani, Elham,Sargolzaei, Javad,etc.The role of adiponectin and adipolin as anti-inflammatory adipokines in the formation of macrophage foam cells and their association with cardiovascular diseases[J].2018,54.
[43]Grimes CA,Jope RS.CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium.[J].2001,78(6).
[44]Lovren, Fina,Yi Pan,Quan, Adrian,etc.Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages.[J].2010,68(3).
[45]Keila Lopes Mendes,Deborah de Farias Lelis,Sérgio Henrique Sousa Santos.Nuclear sirtuins and inflammatory signaling pathways[J].2017,38.
[46]Zhang, Miao,Zhu, Huaiping,Ding, Ye,etc.AMP-activated protein kinase alpha 1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation[J].2017,292(19).
[47]Li, Jia,Wang, Yilei,Wang, Yapu,etc.Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction[J].2015,86.
[48]Bianco, Andrea,Nigro, Ersilia,Monaco, Maria Ludovica,etc.The burden of obesity in asthma and COPD: Role of adiponectin[J].2017,43.
[49]Surya, Ramachandran,Anandan, Vinitha,Cheranellore Chandrasekharan, Kartha.Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus.[J].2016,(1).