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New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension

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Author:
No author available
Journal Title:
Acta Physiologica Sinica
Issue:
6
DOI:
10.13294/j.aps.2018.0088
Key Word:
果糖;盐敏感性高血压;肾素原受体;肾内肾素-血管紧张素系统;Na/H交换子3;Na/K/2Cl共转运体;尿酸;一氧化氮;活性氧;fructose;salt-sensitive hypertension;intrarenal renin-angiotensin system;(pro)renin receptor;nephron ion transporter;uric acid;nitric oxide;reactive oxygen species

Abstract: Fructose intake has increased dramatically over the past century and the upward trend has continued until recently.Increasing evidence suggests that the excessive intake of fructose induces salt-sensitive hypertension.While the underlying mechanism is complex,the kidney likely plays a major role.This review will highlight recent advances in the renal mechanisms of fructose-induced salt-sensitive hypertension,including (pro)renin receptor-dependent activation of intrarenal renin-angiotensin system,increased nephron Na+ transport activity via sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter,increased renal uric acid production,decreased renal nitric oxide production,and increased renal reactive oxygen species production,and suggest actions based on these mechanisms that have therapeutic implications.

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