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Research progress of the relationship between liver X receptor and inflammatory-related diseases

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2018.0012

Key Word:: 肝X受体;炎症相关疾病;抗炎机制

Abstract：肝X受体(liver Xreceptors,LXRs)属核受体超家族成员,它活化后具有多种生物学功能,不仅可调控胆固醇、脂肪酸及葡萄糖等物质的代谢,而且在免疫炎症反应中发挥重要作用.众多研究表明,LXRs在炎症相关疾病的发生及发展过程中扮演重要角色,它可抑制神经系统、呼吸系统及心血管系统等全身多个系统炎症相关疾病的炎症反应.本文从LXRs的结构、功能及抗炎机制等方面,将近年来LXRs与炎症相关疾病关系的研究进展作一综述,为炎症相关疾病的治疗提供新思路.

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