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The role of adventitia in hypoxic vascular remodeling

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 2

DOI:: 10.13294/j.aps.2018.0025

Key Word:: 外膜;低氧;成纤维细胞;滋养血管;低氧诱导因子-1α

Abstract：血管外膜作为调节血管功能关键因子的生成、储存和释放的重要部位,在某些条件下被认为可能是血管壁的损伤感受组织.外膜细胞通常首先响应血管应激或损伤,进而影响血管壁的结构和功能.越来越多的证据表明,在低氧及相关的肺动脉高压、动脉粥样硬化等疾病引起的血管重塑过程中外膜的改变是最早、最突出的.成纤维细胞在血管对局部微环境改变的适应调节方面发挥了重要的作用.本文重点就血管外膜在低氧诱导血管重塑中的作用及其可能的分子机制进行综述.

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