Abstract： Depression is a common mood disorder,which is harmful to public health critically.Gastrointestinal diseases are a series of diseases with both dynamic changes and organic disease,including functional gastrointestinal disease,gastroesophageal reflux disease,gastritis,and gastric ulcer.In recent years,the phenomena of comorbid depression and gastrointestinal disease have become common,however,most patients were diagnosed as unilateral depression or gastrointestinal disease in the clinical treatment process,resulting in delayed treatment or even invalid.The present review focuses on some of the clinical symptoms of comorbid depression and gastrointestinal disease,and begins to explore the possible pathogenesis,so as to find out the potential neurobiological pathways of comorbidity.Consequently,the more attention on comorbid depression and gastrointestinal disease will be paid,and the clinical and basic research of comorbidity and the drug development will be provided.