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The relationship of autophagy with endoplasmic reticulum stress and its role in pathogenesis, prevention and therapy of atherosclerosis

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2017.0046

Key Word:: 自噬;动脉粥样硬化;内质网应激;治疗靶点;autophagy;atherosclerosis;endoplasmic reticulum stress;therapeutic target

Abstract： Autophagy is a cellular catabolic process responsible for removing the injured proteins and organelles via lysosome-dependent pathway,and it plays an important role in maintaining cellular homeostasis.Recent studies have shown that autophagy is activated and implicated in the pathogenesis of atherosclerosis.Autophagy can be triggered by oxidative lipids,cytokines and advanced glycation end products,and exerts protective or detrimental functions in the progression of atherosclerosis.However,the precise role and mechanisms of autophagy in different stages of atherosclerosis are still not fully clarified.This review highlights recent findings regarding autophagy response in vascular cells and its potential contribution to atherogenesis.Additionally,the relationship of autophagy with endoplasmic reticulum stress and whether autophagy could be a new therapeutic target for atherosclerosis are also discussed.

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