Paper - WANFANG MED ONLINE

You Position: Home > Paper

Iron metabolism and neonatal hypoxic ischemic brain damage

( views:16, downloads:0 )

Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 2

DOI:: 10.13294/j.aps.2016.0103

Key Word:: 铁代谢;缺氧缺血性脑损伤;铁蓄积;iron metabolism;hypoxic ischemic brain damage;iron accumulation

Abstract： Iron is an essential element for nervous system development,and maintaining a normal iron level in nervous system is controlled by multiple factors.Recent studies reported that iron dysregulation and the following iron metabolic pathways played an important role in hypoxic ischemic brain damage (HIBD) in neonates.Circulatory iron level is altered after hypoxia-ischemia exposure,which may cause abnormal iron deposition in the nervous system followed by neuronal injury.Finding the causing factors for abnormal iron metabolism after hypoxia-ischemia exposure,as well as understanding the mechanisms how iron metabolism contributes to HIBD,will shed lights on HIBD prevention and treatment.In this mini-review,we summarized changes in iron metabolism after neonatal hypoxia-ischemia exposure,its possible regulatory factors and how iron abnormalities contribute to HIBD.

Reference

[1]余涛,廖清奎,罗春华,等.脑组织铁分布与新生儿缺氧缺血性脑损伤[J].2001,16(4).
[2]黄海波,殷小成,刘海英,等.新生儿缺氧缺血性脑病血清铁和血清铁蛋白的动态变化及意义[J].2011,26(2).
[3]张新华,秦桂秀,关函洲.红细胞膜Na+-K+-ATP酶活性红细胞膜流动性在新生儿缺氧缺血性脑病中的变化及其意义[J].2011,(8).
[4]Qing, Lu,Valerie A, Harris,Ruslan, Rafikov,etc.Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism.[J].2015,6.
[5]Guo, Jing,Chen, Qianwei,Tang, Jun,etc.Minocycline-induced attenuation of iron overload and brain injury after experimental germinal matrix hemorrhage[J].2015,1594.
[6]Magdalena, Che?chowska,Leszek, Lewandowski,Jadwiga, Ambroszkiewicz,etc.[The effect of tobacco smoking during pregnancy on concentration of pro-hepcidin and some parameters of iron metabolism in matched-maternal cord pairs].[J].2008,65.
[7]Meoded,A.,Poretti,A.,Northington,F.J.,etc.Susceptibility weighted imaging of the neonatal brain[J].2012,67(8).
[8]Mary Dawn, Koenig,Lisa, Tussing-Humphreys,Jessica, Day,etc.Hepcidin and iron homeostasis during pregnancy.[J].2014,6.
[9]Gillipsie Minhas,Shweta Modgil,Akshay An.Role of iron in ischemia-induced neurodegeneration: mechanisms and insights[J].2014,29(3).
[10]Jacques-Olivier Coq,Maxime Delcour,Vicky S Massicotte,etc.Prenatal ischemia deteriorates white matter, brain organization, and function: implications for prematurity and cerebral palsy[J].2016,(S4).
[11]Guardia Clausi, M.,Paez, P. M.,Pasquini, L. A.,etc.Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain[J].2016,109.
[12]Zheng,W.,Monnot,A.D..Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases[J].2012,133(2).
[13]I, Cavill,M, Worwood,A, Jacobs.Internal regulation of iron absorption.[J].1975,256.
[14]Guofen, Gao,Yan-Zhong, Chang.Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases.[J].2014,5.
[15].Perinatal role of hepcidin and iron homeostasis in full-term intrauterine growth-restricted infants[J].2013,90(1).
[16]Eric, Mills,Xian-Ping, Dong,Fudi, Wang,etc.Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders.[J].2010,2.
[17]Harned,J.,Nagar,S.,McGahan,M.C..Hypoxia controls iron metabolism and glutamate secretion in retinal pigmented epithelial cells[J].2014,1840(10).
[18]Magdalena, Che?chowskai,Joanna, Gajewska,Mariusz, O?tarzewski,etc.[Umbilical cord serum hepcidin levels and maternal smoking during pregnancy].[J].2015,72.
[19]Todorich B,Pasquini JM,Garcia CI,etc.Oligodendrocytes and Myelination: The Role of Iron[J].2009,57(5).
[20]Derugin,N.,Lee,S.Y.,Daneman,R.,etc.Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat[J].2012,32(28).
[21]Haase,V.H..Regulation of erythropoiesis by hypoxia-inducible factors[J].2013,27(1).
[22]Rathnasamy G,Ling EA,Kaur C.Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species.[J].2011,31(49).
[23]Spicer, Julie,Xu, Dongrong,Monk, Catherine,etc.Maternal prenatal iron status and tissue organization in the neonatal brain[J].2016,79(3).
[24]Kaur, Charanjit,Sivakumar, Viswanathan,Rathnasamy, Gurugirijha,etc.Vascular changes in the developing rat retina in response to hypoxia[J].2015,130.
[25]Zhang X,Connor JR,Slagle-Webb B,etc.Cellular iron status influences the functional relationship between microglia and Oligodendrocytes[J].2006,54(8).
[26]Finberg,K.E..Regulation of systemic iron homeostasis[J].2013,20(3).
[27]Petrova, Julia,Manolov, Victor,Vasilev, Vasil,etc.Ischemic stroke, inflammation, iron overload - Connection to a hepcidin[J].2016,11(1).
[28]Ning, Ning,Zhang, Lei,Gao, Jie,etc.Assessment of Iron Deposition and White Matter Maturation in Infant Brains by Using Enhanced T2 Star Weighted Angiography (ESWAN): R2* versus Phase Values.[J].2014,9(2).
[29]Allison R Greminger,Dawn L Lee,Peter Shrager,etc.Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats.[J].2014,144(7).
[30]Widness JA,Lott DG,Kling PJ,etc.Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia.[J].2005,116(2).
[31]Yi Yu, Deng,Jia, Lu,Eng-Ang, Ling,etc.Role of microglia in the process of inflammation in the hypoxic developing brain.[J].2011,3.
[32]R B, Dietrich,W G, Bradley.Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children.[J].1988,168.
[33]Bastian, Thomas W.,Santarriaga, Stephanie,Nguyen, Thu An,etc.Fetal and neonatal iron deficiency but not copper deficiency increases vascular complexity in the developing rat brain[J].2015,18(8).
[34]Perrone, Serafina,Tataranno, Luisa M.,Stazzoni, Gemma,etc.Brain susceptibility to oxidative stress in the perinatal period[J].2015,28(Suppl.1).
[35]Domellof, Magnus,Georgieff, Michael K..Postdischarge Iron Requirements of the Preterm Infant[J].2015,167(4 Suppl.1).
[36]Murray-Kolb,L.E..Iron and brain functions[J].2013,16(6).
[37]Connor JR,Burdo JR,Haile DJ,etc.Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat.[J].2001,66(6).
[38]Merelli, A.,Czornyj, L.,Lazarowski, A..Erythropoietin as a new therapeutic opportunity in brain inflammation and neurodegenerative diseases[J].2015,125(11).
[39]Karuppagounder, Saravanan S.,Kumar, Arnit,Shao, Diana S.,etc.Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases[J].2015,1628(Pt.B).
[40]Rathnasamy, Gurugirijha,Murugan, Madhuvika,Ling, Eng-Ang,etc.Hypoxia-Induced Iron Accumulation in Oligodendrocytes Mediates Apoptosis by Eliciting Endoplasmic Reticulum Stress[J].2016,53(7).
[41]Aly H,Mesbah A,Shouman BO.Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy.[J].2008,28(7).